GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2274459 | 1 | rs12195409 | chr6:33757482 | IP6K3 | chr6:33689443-33714762:- | 0.28 | 4.89 | 1.16E-6 | Obesity (extreme) |
| BRCA | cis | rs12195417 | 1 | rs12195417 | chr6:84173028 | PRSS35 | chr6:84222274-84235419:+ | -0.11 | -3.5 | 0.000491 | Schizophrenia |
| BRCA | cis | rs12196860 | 1 | rs12196050 | chr6:55985113 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.84 | 1.36E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12196213 | chr6:55932547 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.94 | 6.82E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12196526 | chr6:55955754 | COL21A1 | chr6:55921389-56258892:- | 0.34 | 6.33 | 3.49E-10 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12196670 | chr6:55941044 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.91 | 8.37E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12196709 | chr6:55941100 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.91 | 8.37E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12196860 | chr6:55950374 | COL21A1 | chr6:55921389-56258892:- | -0.35 | -6.49 | 1.28E-10 | Psychosis (atypical) |
| BRCA | cis | rs9473555 | 1 | rs12196937 | chr6:49382808 | CENPQ | chr6:49431096-49460820:+ | -0.23 | -7.34 | 4.22E-13 | Folate pathway vitamin levels |
| BRCA | cis | rs9473555 | 1 | rs12196937 | chr6:49382808 | MUT | chr6:49398994-49431031:- | 0.32 | 10.1 | 5.83E-23 | Folate pathway vitamin levels |
| BRCA | cis | rs12196860 | 1 | rs12196944 | chr6:55941564 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.91 | 8.37E-12 | Psychosis (atypical) |
| BRCA | cis | rs9487094 | 1 | rs12197114 | chr6:109735498 | AKD1 | chr6:109814059-110012415:- | -0.13 | -3.64 | 0.000281 | Height |
| BRCA | cis | rs9487094 | 1 | rs12197114 | chr6:109735498 | SMPD2 | chr6:109761931-109765121:+ | 0.23 | 6.91 | 8.54E-12 | Height |
| BRCA | cis | rs12197419 | 1 | rs12197419 | chr6:1709037 | FOXF2 | chr6:1390069-1395831:+ | -0.11 | -3.72 | 0.000212 | Monobrow thickness |
| BRCA | cis | rs12196860 | 1 | rs12197951 | chr6:55946916 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -7.07 | 2.85E-12 | Psychosis (atypical) |